Media and local sources said the US airstrikes hit al-Bukamal city in the province of Deir Ezzor near the border with Iraq on Monday, killing four and inflicting heavy losses on properties.
The US-led coalition has been conducting air raids against what are alleged to be ISIS hideouts inside Syria since September 2014 without any authorization from Damascus or a UN mandate.
The coalition has repeatedly been accused of targeting and killing civilians. It has also been largely incapable of realizing its declared objective of annihilating ISIS.
Also on Monday, ISIS terrorists fired rockets at al-Qusour and al-Joura neighborhoods in the same province, leaving three civilians, including a girl, dead and 14 others wounded.
Deir Ezzor Province links the ISIS stronghold in the city of Raqqa with territory controlled by the militant group in neighboring Iraq.
Separately, a woman was killed in Qamishli city of Hasakah province in a mortar attack launched from Turkey, local sources said.
Turkey’s border guards also shot and injured a girl near her house in Ras al-Ain city on the border with Turkey.
Turkey has time and again been accused of aiding and abetting militant groups operating in Syria.
Reports say Ankara actively trains and arms Takfiri militants there and facilitates their safe passage into Syria. Ankara has also been accused of buying smuggled oil from ISIS.